By John Frederick Walker
In a definite Curve of Horn, veteran journalist John Frederick Walker tells the tale of 1 of the main respected and endangered of the regal beasts of Africa: the enormous sable antelope of Angola, an impressive, coal-black quadruped with breathtaking curved horns over 5 toes lengthy. it really is a charming and tragic story of exploration and event, politics and conflict, the brutal realities of existence in Africa this present day and the sour offerings of conflicting conservation strategies.
A convinced Curve of Horn strains the sable's emergence as a hugely sought-after usual heritage prize sooner than the 1st international struggle, and follows its fight to outlive in a conflict region fought over by means of the troops of part a dozen international locations, and its transformation right into a political image and conservation icon. As he follows the path of this mysterious animal, Walker interweaves the tales of the adventurers, scientists, and warriors who've come below the thrall of the beast, and the way their activities could form the destiny of the large sable antelope and the heritage of the war-torn kingdom that's its in basic terms domestic.
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Additional info for A Certain Curve of Horn: The Hundred-Year Quest for the Giant Sable Antelope of Angola
Confirm that c-Myc binds to a candidate regulatory site in c13orf25. A predicted target of two of the encoded miRNAs is the transcription factor E2F1, which is itself a critical regulator of the cell cycle. O’Donnell et al. demonstrate that this prediction is correct, and that expression of E2F1 is only affected if the miRNA target site is present in the E2F1 mRNA. E2F1 and c-Myc are known to induce each other’s expression. In the absence of other controls, this could set up a positive-feedback loop leading to overexpression of both genes — with disastrous consequences for normal cell-cycle regulation.
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Remarkably, two of these are encoded by the c13orf25 cluster and the remainder are encoded by two related clusters on chromosomes 7 and X. O’Donnell et al. confirm that c-Myc binds to a candidate regulatory site in c13orf25. A predicted target of two of the encoded miRNAs is the transcription factor E2F1, which is itself a critical regulator of the cell cycle. O’Donnell et al. demonstrate that this prediction is correct, and that expression of E2F1 is only affected if the miRNA target site is present in the E2F1 mRNA.
A Certain Curve of Horn: The Hundred-Year Quest for the Giant Sable Antelope of Angola by John Frederick Walker